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We used single-molecule FRET experiments to monitor the conformational equilibrium of a DNA hairpin under pressure-stress in the presence of an aqueous two-phase system mimicking intracellular liquid-liquid phase separation (LLPS).… Click to show full abstract
We used single-molecule FRET experiments to monitor the conformational equilibrium of a DNA hairpin under pressure-stress in the presence of an aqueous two-phase system mimicking intracellular liquid-liquid phase separation (LLPS). Our data demonstrate the important role of LLPS with its immanent strong excluded volume effect in rescuing biological function under harsh environmental conditions.
Keywords:
phase;
liquid;
hairpin pressure;
pressure stress;
dna hairpin;
liquid liquid
Journal Title: Chemical communications
Year Published: 2019
Link to full text (if available)
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Journal Title: Chemical communications
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!