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Determination of nucleobase-pairing free energies from rotamer equilibria of 2-(methylamino)pyrimidines.

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A fast straightforward method for the determination of free energies of modified nucleobase pairing is proposed. The method is based on the nuclear magnetic resonance (NMR) spectroscopy monitoring of conformational… Click to show full abstract

A fast straightforward method for the determination of free energies of modified nucleobase pairing is proposed. The method is based on the nuclear magnetic resonance (NMR) spectroscopy monitoring of conformational changes of 2-(methylamino)-pyrimidines upon intermolecular binding.

Keywords: pairing free; methylamino pyrimidines; free energies; determination nucleobase; nucleobase pairing

Journal Title: Chemical communications
Year Published: 2019

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