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A new chemical approach for proximity labelling of chromatin-associated RNAs and proteins with visible light irradiation.

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A new nucleus-localized singlet oxygen generator was designed and synthesized. Its capability to label nucleus-localized biomolecules through spatially-restricted oxidation under visible light was validated using fluorescence confocal microscopy. Western blot… Click to show full abstract

A new nucleus-localized singlet oxygen generator was designed and synthesized. Its capability to label nucleus-localized biomolecules through spatially-restricted oxidation under visible light was validated using fluorescence confocal microscopy. Western blot and RT-qPCR were performed to verify the desirable spatial resolution through enriching chromatin-associated RNAs and proteins.

Keywords: new chemical; visible light; chromatin associated; associated rnas; rnas proteins

Journal Title: Chemical communications
Year Published: 2019

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