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A novel method to engineer proteases for selective enzyme inhibition.

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In this work, we have proposed a new strategy to expand the function of a protein. By taking a protease as an example, it can be engineered to make up… Click to show full abstract

In this work, we have proposed a new strategy to expand the function of a protein. By taking a protease as an example, it can be engineered to make up the shortcoming of natural proteases, and thus it can efficiently and selectively hydrolyze a desired protein even in a complex biological fluid.

Keywords: proteases selective; selective enzyme; novel method; enzyme inhibition; engineer proteases; method engineer

Journal Title: Chemical communications
Year Published: 2019

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