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Reductive amidation of alkyl tosylates with isocyanates using the Ni/Co-dual catalytic system is disclosed. The method proceeds efficiently under mild conditions, giving rise to the corresponding alkyl amides. Notably, the… Click to show full abstract
Reductive amidation of alkyl tosylates with isocyanates using the Ni/Co-dual catalytic system is disclosed. The method proceeds efficiently under mild conditions, giving rise to the corresponding alkyl amides. Notably, the protocol can discriminate the steric environment of two alkyl tosylate moieties, enabling regioselective mono-amidation at the less-bulky site.
Keywords:
alkyl;
tosylates isocyanates;
alkyl tosylates;
amidation;
reductive amidation;
amidation alkyl
Journal Title: Chemical communications
Year Published: 2020
Link to full text (if available)
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Journal Title: Chemical communications
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!