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The role of S-bond in tenoxicam keto–enolic tautomerization

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A non-covalent interaction between the sulphur atom of thiophenyl moiety and oxygen of the carbonyl group (S-bond) plays a crucial role in keto–enol tautomerization of tenoxicam leading to the crystallization… Click to show full abstract

A non-covalent interaction between the sulphur atom of thiophenyl moiety and oxygen of the carbonyl group (S-bond) plays a crucial role in keto–enol tautomerization of tenoxicam leading to the crystallization of latter only in zwitterionic (ZWC) and not in β-keto–enolic (BKE) form.

Keywords: role bond; keto; tautomerization; keto enolic

Journal Title: CrystEngComm
Year Published: 2019

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