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Hydrazo coupling: the efficient transition-metal-free C–H functionalization of 8-hydroxyquinoline and phenol through base catalysis

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A new reaction involving the quantitative coupling of phenolic substrates to azodicarboxylate esters under mild conditions is a facile route for obtaining hydrazine derivatives. A plausible mechanism, catalysts, scope and… Click to show full abstract

A new reaction involving the quantitative coupling of phenolic substrates to azodicarboxylate esters under mild conditions is a facile route for obtaining hydrazine derivatives. A plausible mechanism, catalysts, scope and application are discussed.

Keywords: hydrazo coupling; coupling efficient; free functionalization; transition metal; efficient transition; metal free

Journal Title: Green Chemistry
Year Published: 2019

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