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The Pd-catalyzed multicomponent reactions of NH-sulfoximine, aryl iodide and norbornadiene (NBD) are reported to chemoselectively produce fused medium-sized sulfoximine polyheterocycles in good to excellent yields. The addition of the dibenzylideneacetone… Click to show full abstract
The Pd-catalyzed multicomponent reactions of NH-sulfoximine, aryl iodide and norbornadiene (NBD) are reported to chemoselectively produce fused medium-sized sulfoximine polyheterocycles in good to excellent yields. The addition of the dibenzylideneacetone (dba) ligand was found to be useful for this tandem annulation reaction. Under the optimized conditions, a broad range of 3D-type heterocyclic sulfoximines with good functional group tolerance were generated.
Keywords:
fused medium;
sized sulfoximine;
medium sized;
produce fused;
sulfoximine polyheterocycles
Journal Title: Organic chemistry frontiers
Year Published: 2019
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Journal Title: Organic chemistry frontiers
Year Published: 2019
Link to full text (if available)
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recommendations!