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A facile and efficient approach for the direct thiocyanation of pyrazolin-5-ones via a radical mechanism has been established for the first time. A series of 4-thiocyanated 5-hydroxy-1H-pyrazoles were synthesized in… Click to show full abstract
A facile and efficient approach for the direct thiocyanation of pyrazolin-5-ones via a radical mechanism has been established for the first time. A series of 4-thiocyanated 5-hydroxy-1H-pyrazoles were synthesized in fair to good yields by K2S2O8-promoted direct thiocyanation of pyrazolin-5-ones with NH4SCN at room temperature under simple and mild reaction conditions with atom- and step-economy and good functional group tolerance.
Keywords:
k2s2o8 promoted;
direct thiocyanation;
pyrazolin ones;
thiocyanation pyrazolin
Journal Title: Organic chemistry frontiers
Year Published: 2020
Link to full text (if available)
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Journal Title: Organic chemistry frontiers
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!