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An unprecedented synthesis of 4-ethenyl quinazolines via a Rh(III)-catalyzed C–H activation and annulation reaction was described. In particular, when C-alkyl imidamides are benzyl groups, 2-benzoyl quinazolines can be obtained. This… Click to show full abstract
An unprecedented synthesis of 4-ethenyl quinazolines via a Rh(III)-catalyzed C–H activation and annulation reaction was described. In particular, when C-alkyl imidamides are benzyl groups, 2-benzoyl quinazolines can be obtained. This protocol enables the effective application of cyclopropenones, featuring high atom efficiency, broad substrate scope and mild reaction conditions.
Keywords:
ethenyl quinazolines;
iii catalyzed;
reaction;
synthesis ethenyl;
quinazolines via;
annulation reaction
Journal Title: Organic chemistry frontiers
Year Published: 2020
Link to full text (if available)
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Journal Title: Organic chemistry frontiers
Year Published: 2020
Link to full text (if available)
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recommendations!