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Small DNA circles as bacterial topoisomerase I inhibitors

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It is demonstrated that small DNA circles showed high inhibitory effect on the activity of bacterial topoisomerase I and the single-stranded regions associated with bending deformation are believed to be… Click to show full abstract

It is demonstrated that small DNA circles showed high inhibitory effect on the activity of bacterial topoisomerase I and the single-stranded regions associated with bending deformation are believed to be the crucial factor for trapping the enzymes.

Keywords: circles bacterial; small dna; bacterial topoisomerase; dna circles; topoisomerase inhibitors

Journal Title: RSC Advances
Year Published: 2019

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