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Synthesis, human topoisomerase IIα inhibitory properties and molecular modeling studies of anti-proliferative curcumin mimics

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Piperidinecarboxamides (curcumin mimics) show promising anti-proliferative properties against HCT116 (colon), MCF7 (breast) and A431 (squamous skin) carcinoma cell lines with potency higher than that of 5-fluorouracil. Click to show full abstract

Piperidinecarboxamides (curcumin mimics) show promising anti-proliferative properties against HCT116 (colon), MCF7 (breast) and A431 (squamous skin) carcinoma cell lines with potency higher than that of 5-fluorouracil.

Keywords: human topoisomerase; anti proliferative; synthesis human; topoisomerase inhibitory; inhibitory properties; curcumin mimics

Journal Title: RSC Advances
Year Published: 2019

Link to full text (if available)


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