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Metal-free oxidative trifluoromethylation of indoles with CF3SO2Na on the C2 position

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An efficient method of synthesizing 2-trifluoromethylindoles from indoles with easy-to-handle, cheap and low-toxic CF3SO2Na under metal-free conditions is described, which selectively introduces trifluoromethyl to indoles on the C2 position. Click to show full abstract

An efficient method of synthesizing 2-trifluoromethylindoles from indoles with easy-to-handle, cheap and low-toxic CF3SO2Na under metal-free conditions is described, which selectively introduces trifluoromethyl to indoles on the C2 position.

Keywords: free oxidative; position; indoles cf3so2na; metal free; oxidative trifluoromethylation; trifluoromethylation indoles

Journal Title: RSC Advances
Year Published: 2019

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