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Synthesis and biological evaluation of geldanamycin–ferulic acid conjugate as a potent Hsp90 inhibitor

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Compared to 17-AAG, LZY228 exhibited higher Hsp90 inhibitory activity in vitro and better antitumor activity in human breast carcinoma (MDA-MB-231) xenograft nude mice. Click to show full abstract

Compared to 17-AAG, LZY228 exhibited higher Hsp90 inhibitory activity in vitro and better antitumor activity in human breast carcinoma (MDA-MB-231) xenograft nude mice.

Keywords: biological evaluation; acid conjugate; evaluation geldanamycin; geldanamycin ferulic; ferulic acid; synthesis biological

Journal Title: RSC Advances
Year Published: 2019

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