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Directed C(sp3)–H arylation of tryptophan: transformation of the directing group into an activated amide

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The aminoquinoline-directed C–H activation was used to synthezise unnatural tryptophans for solid phase peptide synthesis for the first time. Click to show full abstract

The aminoquinoline-directed C–H activation was used to synthezise unnatural tryptophans for solid phase peptide synthesis for the first time.

Keywords: transformation directing; sp3 arylation; arylation tryptophan; directed sp3; tryptophan transformation; directing group

Journal Title: Chemical Science
Year Published: 2019

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