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How many cells are enough for single-cell infrared spectroscopy?

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The influence of cell number on spectral variability among two different cell types and two states was quantitatively analyzed and evaluated by calculating the similarity distance of the single-cell spectral… Click to show full abstract

The influence of cell number on spectral variability among two different cell types and two states was quantitatively analyzed and evaluated by calculating the similarity distance of the single-cell spectral data obtained from synchrotron infrared microspectroscopy. We found that at least 15 cells are required to achieve robust results with 95% confidence.

Keywords: single cell; cells enough; many cells; spectroscopy; enough single; cell

Journal Title: Chemical communications
Year Published: 2020

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