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Palladium-catalyzed asymmetric hydrogenation of 2-aryl cyclic ketones for the synthesis of trans cycloalkanols through dynamic kinetic resolution under acidic conditions.

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The first efficient palladium-catalyzed asymmetric hydrogenation of 2-aryl cyclic ketones has been described through dynamic kinetic resolution under acidic conditions, providing a facile access to chiral trans cycloalkanol derivatives with… Click to show full abstract

The first efficient palladium-catalyzed asymmetric hydrogenation of 2-aryl cyclic ketones has been described through dynamic kinetic resolution under acidic conditions, providing a facile access to chiral trans cycloalkanol derivatives with excellent enantioselectivities.

Keywords: catalyzed asymmetric; hydrogenation aryl; aryl cyclic; asymmetric hydrogenation; palladium catalyzed; cyclic ketones

Journal Title: Chemical communications
Year Published: 2020

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