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The operation of DNA nanodevices is often limited by erroneous strand displacement. Here we demonstrate simple design principles that reduce such leakage by up to two orders of magnitude. Enhanced… Click to show full abstract
The operation of DNA nanodevices is often limited by erroneous strand displacement. Here we demonstrate simple design principles that reduce such leakage by up to two orders of magnitude. Enhanced operational robustness against multiple spurious inputs was obtained by simply relocating toehold overhangs to external locations and strengthening adjacent G-C clamping.
Keywords:
sequestered dna;
toehold sequestered;
enhancement fidelity;
conformational enhancement;
fidelity toehold;
dna nanodevices
Journal Title: Chemical communications
Year Published: 2020
Link to full text (if available)
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Journal Title: Chemical communications
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!