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An enantioselective Au(i)-catalyzed cyclization/nucleophilic addition process is developed, starting from 1,5-enyne substrates. A broad scope of O-, N- and C-nucleophiles was introduced in order to provide the corresponding chiral cyclopentene… Click to show full abstract
An enantioselective Au(i)-catalyzed cyclization/nucleophilic addition process is developed, starting from 1,5-enyne substrates. A broad scope of O-, N- and C-nucleophiles was introduced in order to provide the corresponding chiral cyclopentene derivatives in moderate to high yields and up to 96 : 4 enantiomeric ratio.
Keywords:
cyclization intermolecular;
catalyzed cyclization;
cyclization;
enantioselective gold;
intermolecular nucleophilic;
gold catalyzed
Journal Title: Chemical communications
Year Published: 2020
Link to full text (if available)
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Journal Title: Chemical communications
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!