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Solid-phase synthesis of DNA-encoded libraries via an "aldehyde explosion" strategy.

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We report chemistry suitable for the solid-phase synthesis of DNA-encoded libraries with an unusually high level of structural diversity. The strategy involves "exploding" an immobilized aldehyde into a plethora of… Click to show full abstract

We report chemistry suitable for the solid-phase synthesis of DNA-encoded libraries with an unusually high level of structural diversity. The strategy involves "exploding" an immobilized aldehyde into a plethora of different functional groups under DNA-compatible conditions.

Keywords: phase synthesis; dna encoded; solid phase; synthesis dna; encoded libraries

Journal Title: Chemical communications
Year Published: 2020

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