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Ribosomal incorporation of cyclic β-amino acids into peptides using in vitro translation.

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We demonstrate in vitro incorporation of cyclic β-amino acids into peptides by the ribosome through genetic code reprogramming. Further, we show that incorporation efficiency can be increased through the addition… Click to show full abstract

We demonstrate in vitro incorporation of cyclic β-amino acids into peptides by the ribosome through genetic code reprogramming. Further, we show that incorporation efficiency can be increased through the addition of elongation factor P.

Keywords: incorporation cyclic; amino acids; cyclic amino; acids peptides; incorporation

Journal Title: Chemical communications
Year Published: 2020

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