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Fluorescence imaging of hypochlorous acid and peroxynitrite in vitro and in vivo with emission wavelength beyond 750 nm.

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A series of near-infrared and photostable Si-oxazine fluorescent dyes was synthesized using a simple three-step procedure, and one of their reduced products, i.e. hydro-Si-oxazine HSiO3, has been utilized to sensitively… Click to show full abstract

A series of near-infrared and photostable Si-oxazine fluorescent dyes was synthesized using a simple three-step procedure, and one of their reduced products, i.e. hydro-Si-oxazine HSiO3, has been utilized to sensitively detect hypochlorous acid and peroxynitrite generation by phagocytes in inflamed and pulmonary fibrosis diseased mice with emission wavelength beyond 750 nm.

Keywords: acid peroxynitrite; wavelength beyond; beyond 750; emission wavelength; hypochlorous acid

Journal Title: Chemical communications
Year Published: 2020

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