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Step and redox efficient nitroarene to indole synthesis.

Step and redox efficiencies are a rising priority in synthetic method development, in order to make synthetic processes more sustainable and more affordable. Herein, a step and redox efficient nitroarene… Click to show full abstract

Step and redox efficiencies are a rising priority in synthetic method development, in order to make synthetic processes more sustainable and more affordable. Herein, a step and redox efficient nitroarene to indole synthesis is developed, in sharp contrast to the rich literature on the construction of indoles. Elemental zinc was found to be the best terminal reductant.

Keywords: nitroarene indole; indole synthesis; redox efficient; step redox; efficient nitroarene

Journal Title: Chemical communications
Year Published: 2020

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