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Transmembrane transport of copper(i) by imidazole-functionalised calix[4]arenes.

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Here we present the first synthetic transmembrane transporters for Cu+. Calix[4]arenes with two imidazole groups have a linear coordination motif, which allows selective extraction of Cu+ into chloroform. Transmembrane transport… Click to show full abstract

Here we present the first synthetic transmembrane transporters for Cu+. Calix[4]arenes with two imidazole groups have a linear coordination motif, which allows selective extraction of Cu+ into chloroform. Transmembrane transport of Cu+ into liposomes was investigated with a newly developed assay and the results open the way to biomedical applications of these Cu+ ionophores.

Keywords: transmembrane; calix arenes; transmembrane transport; transport copper; copper imidazole

Journal Title: Chemical communications
Year Published: 2020

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