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Photo-switching of blunt-end stacking between DNA strands immobilized on gold nanoparticles.

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End-to-end intermolecular interaction between double-stranded DNAs grafted onto individual nanoparticles is regulated by terminal base pairing/unpairing triggered by the photo-isomerization of an azobenzene moiety inserted in the vicinity of the… Click to show full abstract

End-to-end intermolecular interaction between double-stranded DNAs grafted onto individual nanoparticles is regulated by terminal base pairing/unpairing triggered by the photo-isomerization of an azobenzene moiety inserted in the vicinity of the DNA terminal. This is the first example of highly reversible control of blunt-end stacking under both isothermal and isoionic-strength conditions.

Keywords: end; photo switching; blunt end; end stacking; switching blunt; stacking dna

Journal Title: Chemical communications
Year Published: 2020

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