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Target-induced molecular-switch on triple-helix DNA-functionalized carbon nanotubes for simultaneous visual detection of nucleic acids and proteins.

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We report an easy and efficient approach based on a target-induced molecular-switch on triple-helix DNA (THD)-functionalized carbon nanotubes (CNTs) for the simultaneous visual detection of nucleic acids and proteins with… Click to show full abstract

We report an easy and efficient approach based on a target-induced molecular-switch on triple-helix DNA (THD)-functionalized carbon nanotubes (CNTs) for the simultaneous visual detection of nucleic acids and proteins with a lateral flow nucleic acid biosensor. The assay had the capability to detect a minimum of 25 pM target DNA and 0.25 nM thrombin simultaneously within 20 min.

Keywords: dna; triple helix; induced molecular; switch triple; target induced; molecular switch

Journal Title: Chemical communications
Year Published: 2020

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