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Dual enzyme responsive mannose-6-phosphate based vesicle for controlled lysosomal delivery.

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Dual enzyme responsive stable biomimetic vesicles composed of mannose-6-phosphate lipid can encapsulate and deliver dual dye/drug and protein/enzyme exclusively to the lysosome in HEK-293 cells. The release of the cargo… Click to show full abstract

Dual enzyme responsive stable biomimetic vesicles composed of mannose-6-phosphate lipid can encapsulate and deliver dual dye/drug and protein/enzyme exclusively to the lysosome in HEK-293 cells. The release of the cargo from the vesicles can be temporally controlled due to the enzyme responsive morphology change of the M6P lipid assembly.

Keywords: dual enzyme; phosphate based; responsive mannose; mannose phosphate; enzyme responsive

Journal Title: Chemical communications
Year Published: 2020

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