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Colchicine is light-sensitive and undergoes electrocyclic reaction upon exposure to light. In this study, the photostability of colchicine was found to be significantly improved via rebalancing the electron density of… Click to show full abstract
Colchicine is light-sensitive and undergoes electrocyclic reaction upon exposure to light. In this study, the photostability of colchicine was found to be significantly improved via rebalancing the electron density of the tropolone ring system after solid form changes. This work may provide a new approach for resolving photo-sensitive challenges during drug development.
Keywords:
photo sensitive;
stabilizing photo;
colchicine;
rebalancing electron;
tropolone ring
Journal Title: CrystEngComm
Year Published: 2021
Link to full text (if available)
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Journal Title: CrystEngComm
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!