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The CXCR4 chemokine receptor is an important biomolecular target in cancer diagnostics and therapeutics. In a new multivalent approach, iron oxide nanoparticles were conjugated with multiple binding units of a… Click to show full abstract
The CXCR4 chemokine receptor is an important biomolecular target in cancer diagnostics and therapeutics. In a new multivalent approach, iron oxide nanoparticles were conjugated with multiple binding units of a low affinity azamacrocylic CXCR4 antagonist. The silica coated nanostructure has good suspension stability, a mode size of 72 nm and high affinity for CXCR4, showing >98% inhibition of anti-CXCR4 mAb binding in a receptor binding competition assay on Jurkat cells.
Keywords:
iron oxide;
oxide nanoparticles;
cxcr4 chemokine;
receptor;
chemokine receptor
Journal Title: Dalton transactions
Year Published: 2021
Link to full text (if available)
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Journal Title: Dalton transactions
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!