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Concanavalin A targeting N-linked glycans in spike proteins influence viral interactions.

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Lectins, which exhibit viral-interaction abilities, have garnered attention in the current pandemic era as potential neutralizing agents and vaccine candidates. Viral invasion through envelope proteins is modulated by N-linked glycosylation… Click to show full abstract

Lectins, which exhibit viral-interaction abilities, have garnered attention in the current pandemic era as potential neutralizing agents and vaccine candidates. Viral invasion through envelope proteins is modulated by N-linked glycosylation in the spike (S) protein. This study demonstrates the biophysical aspects between lectins and high-mannose and -galactose N-glycans to provide insights into binding events.

Keywords: spike proteins; linked glycans; concanavalin targeting; proteins influence; glycans spike; targeting linked

Journal Title: Dalton transactions
Year Published: 2020

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