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Enantiospecific on-water bromination: a mild and efficient protocol for the preparation of alkyl bromides

Herein we report the first example of an on-water enantiospecific synthesis of alkyl bromides. This procedure allowed the conversion of secondary activated alkyl sulphides to benzylic alkyl bromides, which were… Click to show full abstract

Herein we report the first example of an on-water enantiospecific synthesis of alkyl bromides. This procedure allowed the conversion of secondary activated alkyl sulphides to benzylic alkyl bromides, which were obtained in high yields and excellent enantioselectivity.

Keywords: water; alkyl bromides; bromination mild; enantiospecific water; water bromination

Journal Title: Green Chemistry
Year Published: 2020

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