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An efficient and general method for the synthesis of coenzyme Q compounds through the activation of the 1,4-benzoquinone Csp2–H bond has been developed. This C–C bond formation reaction proceeds readily… Click to show full abstract
An efficient and general method for the synthesis of coenzyme Q compounds through the activation of the 1,4-benzoquinone Csp2–H bond has been developed. This C–C bond formation reaction proceeds readily in an open flask by the direct cross-coupling reaction of coenzyme Q0 with commercially available aliphatic carboxylic acids utilizing AgNO3 as a catalyst and K2S2O8 as an oxidant in aqueous solution. This radical reaction is operationally simple and amenable to gram-scale synthesis.
Keywords:
agno3 catalyzed;
coupling reaction;
coenzyme;
reaction;
cross coupling
Journal Title: New Journal of Chemistry
Year Published: 2020
Link to full text (if available)
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Journal Title: New Journal of Chemistry
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!