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Cu2O-catalyzed selective 1,2-addition of acetonitrile to α,β-unsaturated aldehydes

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A cyanomethylation of α,β-unsaturated aldehydes with acetonitrile as a nucleophile is disclosed. The reaction is promoted with Cu2O as an inexpensive catalyst. Mild conditions are used, and the reaction completes… Click to show full abstract

A cyanomethylation of α,β-unsaturated aldehydes with acetonitrile as a nucleophile is disclosed. The reaction is promoted with Cu2O as an inexpensive catalyst. Mild conditions are used, and the reaction completes within a few minutes. Through our simple and scalable operation, a large set of δ,γ-unsaturated-β-hydroxyl nitriles are prepared in good to high yields.

Keywords: unsaturated aldehydes; acetonitrile unsaturated; catalyzed selective; addition acetonitrile; cu2o catalyzed; selective addition

Journal Title: Organic chemistry frontiers
Year Published: 2020

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