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Cu/(Ph-pybox)-catalyzed asymmetric dearomative alkynylation of isoquinolines has been realized in high to excellent enantioselectivities (up to 96% ee) with α-bromoacetophenone as an activator and 1,1′-binaphthyl-2,2′-diyl hydrogenphosphate as an additive. This… Click to show full abstract
Cu/(Ph-pybox)-catalyzed asymmetric dearomative alkynylation of isoquinolines has been realized in high to excellent enantioselectivities (up to 96% ee) with α-bromoacetophenone as an activator and 1,1′-binaphthyl-2,2′-diyl hydrogenphosphate as an additive. This novel reaction tolerates a wide variety of functional groups and affords enantioenriched C1-alkynyl 1,2-dihydroisoquinolines in high yields and ee under mild conditions.
Keywords:
dearomative alkynylation;
catalyzed asymmetric;
alkynylation isoquinolines;
asymmetric dearomative;
copper catalyzed
Journal Title: Organic chemistry frontiers
Year Published: 2020
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Journal Title: Organic chemistry frontiers
Year Published: 2020
Link to full text (if available)
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recommendations!