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Regio- and stereoselective halothiolation of alkynes using lithium halides and N-thiosuccinimides

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We have developed a highly regioselective halothiolation of alkynes under simple and mild conditions. Our halothiolation reagents are readily available alkali metal halides and N-thiosuccinimides. Our transition metal-free system offers… Click to show full abstract

We have developed a highly regioselective halothiolation of alkynes under simple and mild conditions. Our halothiolation reagents are readily available alkali metal halides and N-thiosuccinimides. Our transition metal-free system offers good chemical yields for a wide range of alkyne substrates with satisfactory regioselectivity and good functional group tolerance.

Keywords: halides thiosuccinimides; halothiolation; regio stereoselective; stereoselective halothiolation; alkynes using; halothiolation alkynes

Journal Title: Organic chemistry frontiers
Year Published: 2020

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