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The syntheses and crystal structures of a [15]paracyclophenone and its two fluorenone-containing derivatives I and II are reported. The nerve agent mimics binding behaviors with 2 and I driven by… Click to show full abstract
The syntheses and crystal structures of a [15]paracyclophenone and its two fluorenone-containing derivatives I and II are reported. The nerve agent mimics binding behaviors with 2 and I driven by the ‘non-traditional’ aryl-CH hydrogen bonding interactions are demonstrated in the solid state and supported by DFT calculations. The affinity of compound I towards the real nerve agents via this binding mode is also predicted by the computational method.
Keywords:
aryl hydrogen;
agent mimics;
containing derivatives;
fluorenone containing;
nerve agent;
hydrogen bonding
Journal Title: Organic chemistry frontiers
Year Published: 2020
Link to full text (if available)
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Journal Title: Organic chemistry frontiers
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!