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A novel approach to the synthesis of 3,4-dicarbonyl-substituted pyrazoles from a wide range of 1,3-dicarbonyl compounds and oxamic acid thiohydrazides was developed via iodine-promoted cascade imination/halogenation/cyclization/ring contraction reaction accompanied by… Click to show full abstract
A novel approach to the synthesis of 3,4-dicarbonyl-substituted pyrazoles from a wide range of 1,3-dicarbonyl compounds and oxamic acid thiohydrazides was developed via iodine-promoted cascade imination/halogenation/cyclization/ring contraction reaction accompanied by sulfur elimination. This procedure provides a highly efficient and facile route to functionalized pyrazoles from readily available substrates under mild reaction conditions.
Keywords:
oxamic acid;
acid thiohydrazides;
iodine promoted;
synthesis;
dicarbonyl compounds;
compounds oxamic
Journal Title: Organic chemistry frontiers
Year Published: 2020
Link to full text (if available)
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Journal Title: Organic chemistry frontiers
Year Published: 2020
Link to full text (if available)
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recommendations!