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Convergent and convenient regioselective synthesis of novel thiazolo[2,3-a]pyrimidine derivatives was accomplished using the one-pot reaction of 6-ethylthiouracil, bromoacetic acid, anhydrous sodium acetate, acetic anhydride, acetic acid and suitable aldehyde. X-ray… Click to show full abstract
Convergent and convenient regioselective synthesis of novel thiazolo[2,3-a]pyrimidine derivatives was accomplished using the one-pot reaction of 6-ethylthiouracil, bromoacetic acid, anhydrous sodium acetate, acetic anhydride, acetic acid and suitable aldehyde. X-ray crystallographic study reveals the presence of the Z configuration of only one regioisomer confirmed by computational studies as being the most likely isomer present.
Keywords:
arylidene thiazolo;
regioselective convergent;
synthesis arylidene;
thiazolo;
convergent synthesis;
synthesis
Journal Title: RSC Advances
Year Published: 2020
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Journal Title: RSC Advances
Year Published: 2020
Link to full text (if available)
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recommendations!