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We developed conjugates between monoclonal antibody (mAb) and folic acid (FA) by using a tryptophan (Trp)-selective reaction, which yields relatively homogenous products compared to conventional methods. The obtained mAb–FA conjugates… Click to show full abstract
We developed conjugates between monoclonal antibody (mAb) and folic acid (FA) by using a tryptophan (Trp)-selective reaction, which yields relatively homogenous products compared to conventional methods. The obtained mAb–FA conjugates showed significant cellular cytotoxicity toward folate receptor-expressing cancer cells, demonstrating that the conjugates retained the Fc region's original function.
Keywords:
folic acid;
selective reaction;
toward folate;
cancer cells;
folate receptor
Journal Title: RSC Advances
Year Published: 2020
Link to full text (if available)
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Journal Title: RSC Advances
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!