LAUSR

The possibility of 3D printing high temperature and chemically resistant polymers creates opportunities for applications in flow chemistry. Herein we describe the development of milli- and microfluidic reactors made of polyether ether ketone (PEEK) with a high temperature 3D printer and examine their mixing performance and suitability for flow reactions at elevated temperatures. Additionally, we present a 3D-printed separator, back pressure regulator and continuous syringe pump, which provide a complete flow system for a fraction of the cost of commercially available flow equipment. Different 3D printed mixing geometries were tested and the influence of mixing on fluorination of a ribose derivative was evaluated. To demonstrate the usability of our self-made flow equipment we performed a multistep reaction of a ribose derivative in excellent yield which could be used as a precursor for the synthesis of nucleoside anti-cancer drugs.