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We here describe the synthesis of a novel peptide/polymer-conjugate, embedding the amyloid-β (Aβ) protein core sequence Leu-Val-Phe-Phe (LVFF, Aβ17-20) via RAFT polymerization. Based on a novel chain transfer-agent, the "grafting-from"… Click to show full abstract
We here describe the synthesis of a novel peptide/polymer-conjugate, embedding the amyloid-β (Aβ) protein core sequence Leu-Val-Phe-Phe (LVFF, Aβ17-20) via RAFT polymerization. Based on a novel chain transfer-agent, the "grafting-from" approach effectively generates the well-defined peptide-polymer conjugates with appreciably high monomer conversion rate, resulting in mechanically stiffer peptide-functional cross-linked polymeric hydrogels.
Keywords:
raft polymerization;
transfer agent;
chain transfer
Journal Title: Soft matter
Year Published: 2020
Link to full text (if available)
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Journal Title: Soft matter
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!