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Synthesis of 15N-labeled heterocycles via the cleavage of C-N bonds of anilines and glycine-15N.

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A nitrogen replacement process that directly incorporates the 15N atom of glycine-15N into anilines was reported. The process involves a Csp2-N bond cleavage of anilines driven by dearomatization and a… Click to show full abstract

A nitrogen replacement process that directly incorporates the 15N atom of glycine-15N into anilines was reported. The process involves a Csp2-N bond cleavage of anilines driven by dearomatization and a Csp3-N bond cleavage of glycine-15N driven by aromatization. A variety of 15N-labeled aromatic heterocycles can be prepared via this process.

Keywords: glycine 15n; synthesis 15n; cleavage; labeled heterocycles; 15n labeled; glycine

Journal Title: Chemical communications
Year Published: 2021

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