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Structural revision of a Wnt/β-catenin modulator and confirmation of cannabielsoin constitution and configuration.

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In this report, we revise the structure for a previously reported synthetic product proposed to be the 1R,2S-cannabidiol epoxide and reassign it as cannabielsoin using anisotropic NMR and synthetic chemistry… Click to show full abstract

In this report, we revise the structure for a previously reported synthetic product proposed to be the 1R,2S-cannabidiol epoxide and reassign it as cannabielsoin using anisotropic NMR and synthetic chemistry methods. These results provide a direct link to the first known biological target and function of cannabielsoin.

Keywords: structural revision; cannabielsoin; catenin modulator; modulator confirmation; revision wnt; wnt catenin

Journal Title: Chemical communications
Year Published: 2021

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