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A covalent organic framework-based nanoagent for H2S-activable phototherapy against colon cancer.

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Herin, we report a Cu(ii)-porphyrin-derived nanoscale COF, which can be triggered by endogenous H2S via an intracellular sulfidation reaction to generate a metal-free COF-photosensitizer for PDT against H2S-enriched colon tumors… Click to show full abstract

Herin, we report a Cu(ii)-porphyrin-derived nanoscale COF, which can be triggered by endogenous H2S via an intracellular sulfidation reaction to generate a metal-free COF-photosensitizer for PDT against H2S-enriched colon tumors with controllable singlet oxygen release; meanwhile in situ generated CuS can be synchronously used as a photothermal agent for PTT.

Keywords: framework based; h2s; based nanoagent; colon; covalent organic; organic framework

Journal Title: Chemical communications
Year Published: 2021

Link to full text (if available)


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