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Reversible regulation of metallo-base-pair interactions for DNA dehybridization by ultrasound.

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Mechanical force applied by ultrasound in solution leads to the dissociation of DNA metallo-base-pair interactions when these motifs are functionalized with oligodeoxynucleotide sequences of sufficient length. The annealing and force-induced… Click to show full abstract

Mechanical force applied by ultrasound in solution leads to the dissociation of DNA metallo-base-pair interactions when these motifs are functionalized with oligodeoxynucleotide sequences of sufficient length. The annealing and force-induced denaturing process is followed by the attachment of distance-sensitive fluorescent probes and is found to be reversible.

Keywords: pair interactions; metallo base; base pair

Journal Title: Chemical communications
Year Published: 2021

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