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Sensitive imaging of tumors using a nitroreductase-activated fluorescence probe in the NIR-II window.

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A nitroreductase (NTR)-activated NIR-II fluorescence probe for tumor imaging is reported. The probe can emit fluorescence in the range of 900-1300 nm, and target hypoxic tumors with NTR overexpression, thus… Click to show full abstract

A nitroreductase (NTR)-activated NIR-II fluorescence probe for tumor imaging is reported. The probe can emit fluorescence in the range of 900-1300 nm, and target hypoxic tumors with NTR overexpression, thus allowing for accurate delineation of tumor margins through deep penetration.

Keywords: fluorescence; sensitive imaging; nitroreductase; fluorescence probe; imaging tumors

Journal Title: Chemical communications
Year Published: 2021

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