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CtD strategy to construct stereochemically complex and structurally diverse compounds from griseofulvin.

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The Complexity to Diversity (CtD) strategy, a strategy for the synthesis of stereochemically complex and structurally diverse small molecules from natural products using ring-distortion reactions, was applied in the synthesis… Click to show full abstract

The Complexity to Diversity (CtD) strategy, a strategy for the synthesis of stereochemically complex and structurally diverse small molecules from natural products using ring-distortion reactions, was applied in the synthesis of a 47-member compound collection from the natural product griseofulvin. A Tsuji-Trost allylation and oxa-Michael cyclization tandem reaction was used for the first time in the CtD strategy to generate complex ring fused compounds.

Keywords: complex structurally; stereochemically complex; ctd strategy; structurally diverse; strategy construct; strategy

Journal Title: Chemical communications
Year Published: 2021

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