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Synthesis of 1,4-enynes was performed via nickel-catalyzed cross-coupling of allylic alcohols with alkynylzinc reagents. The reaction features high regio- and E/Z-selectivity when aryl-substituted allylic alcohols were employed. The method also… Click to show full abstract
Synthesis of 1,4-enynes was performed via nickel-catalyzed cross-coupling of allylic alcohols with alkynylzinc reagents. The reaction features high regio- and E/Z-selectivity when aryl-substituted allylic alcohols were employed. The method also exhibits a wide scope of substrates and good compatibility of functional groups.
Keywords:
synthesis enynes;
allylic alcohols;
cross coupling;
catalyzed cross;
nickel catalyzed;
via nickel
Journal Title: Chemical communications
Year Published: 2021
Link to full text (if available)
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Journal Title: Chemical communications
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!