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We highlight the reported developments of the palladium-catalyzed C-H activation and functionalization of the inactive/unreactive prochiral C(sp3)-H bonds of aliphatic and alicyclic compounds. There exist numerous classical methods for generating… Click to show full abstract
We highlight the reported developments of the palladium-catalyzed C-H activation and functionalization of the inactive/unreactive prochiral C(sp3)-H bonds of aliphatic and alicyclic compounds. There exist numerous classical methods for generating contiguous stereogenic centers in a compound with a high degree of stereocontrol. Along similar lines, the Pd(II)-catalyzed, directing group-aided functionalization of inactive prochiral/diastereotopic C(sp3)-H bonds have been exploited to accomplish the stereoselective construction of stereo-arrays in organic compounds. We present a concise discussion on how specific strategies consisting of Pd(II)-catalyzed, directing group-aided C(sp3)-H functionalization have been utilized to generate two or more stereogenic centers in aliphatic and alicyclic compounds.
Journal Title: Chemical communications
Year Published: 2022
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