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Silver oxide(I) promoted Conia-ene/radical cyclization for a straightforward access to furan derivatives.

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A novel access to fused furan cores using silver oxide(I) has been developed. Mechanistic investigations indicate the involvement of a Conia-ene reaction/radical cyclization for an expedient path to complex furan… Click to show full abstract

A novel access to fused furan cores using silver oxide(I) has been developed. Mechanistic investigations indicate the involvement of a Conia-ene reaction/radical cyclization for an expedient path to complex furan derivatives. The reaction is broad in scope with interesting atom economy and can also be conducted in a one-pot fashion from readily accessible α,β-unsaturated ketones.

Keywords: furan derivatives; radical cyclization; silver oxide; conia ene; access

Journal Title: Chemical communications
Year Published: 2022

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